Curcuma Longa and Curcumin: Promising Options for Arthritis Treatment
Modern pharmacological research has discovered that the chemical components of Curcuma longa L. are primarily curcumin and volatile turmeric oil. Several recent randomized controlled studies (RCTs) have demonstrated that curcumin improves symptoms and inflammation in patients with arthritis.
Pubmed, Cochran Library, CNKI, and other databases were searched to gather randomized controlled studies (RCTs). The risk of bias in RCTs was assessed, and data were extracted. Finally, RevMan 5.3 was used for meta-analysis.
Twenty-nine randomized controlled studies involving 2,396 participants and 5 types of arthritis were included. The arthritis types included ankylosing spondylitis, rheumatoid arthritis, osteoarthritis, juvenile idiopathic arthritis, and gout/hyperuricemia.
Curcumin and Curcuma longa extract were administered in variable doses ranging from 120 mg to 1,500 mg for a duration of 4-36 weeks. Overall, curcumin and Curcuma longa extract demonstrated safety in all studies and improved the severity of inflammation and pain levels in these arthritis patients.
However, additional randomized controlled studies are needed in the future to clarify the effects of curcumin and Curcuma longa extract in patients with arthritis, including ankylosing spondylitis, rheumatoid arthritis, osteoarthritis, juvenile idiopathic arthritis, and gout/hyperuricemia.
In conclusion, curcumin and Curcuma longa extract can improve symptoms and inflammation levels in individuals with arthritis. However, due to the low quality and limited quantity of randomized controlled studies, the conclusions should be interpreted with caution.
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Source: Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H. Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial. Front Immunol. 2022 Jul 22;13:891822. doi: 10.3389/fimmu.2022.891822. PMID: 35935936; PMCID: PMC9353077.
