Equisetum arvense L. and Palmitoylethanolamide as a Promising Nutraceutical Approach for Neuropathic Pain
Introduction:
Peripheral neuropathies are medical conditions characterized by damage and malfunction of the peripheral nervous system, resulting in symptoms such as pain, tingling, numbness, weakness, loss of muscle tone, balance problems, and difficulty coordinating movements.
In the case of injuries to the peripheral nerves of the upper limbs, this significantly impacts the quality of life and leads to a considerable loss of sensory and motor functions. Standard pharmacological therapies for peripheral neuropathies, including non-steroidal anti-inflammatory drugs (NSAIDs), may lead to addiction, intolerance, and suboptimal treatment outcomes. In recent years, researchers have explored innovative natural sources to alleviate neuropathic pain.
Focus on Equisetum arvense (Field Horsetail):
Among various antioxidant substances, researchers have turned their attention to Equisetum arvense (Field Horsetail), a plant containing several alkaloids, as well as minerals, vitamins, flavonoids, tannins, and saponins. Field Horsetail also exhibits anti-inflammatory properties and has traditionally been used to treat joint pain and swelling associated with arthritis. It is also utilized for its remineralizing and neuroprotective properties.
The Role of Palmitoylethanolamide (PEA):
A recent Italian study evaluated the potential benefits of an oral dietary supplement composed of Field Horsetail and palmitoylethanolamide (PEA), a substance known for its anti-inflammatory and analgesic properties, in alleviating neuropathic pain. The study initially assessed the bioavailability of this combination using a 3D intestinal barrier model to simulate oral intake, evaluating absorption, biodistribution, and excluding cytotoxicity.
Biological Effects on Neuropathy:
Subsequently, a 3D nerve tissue model was developed to study the biological effects of the supplement during key mechanisms underlying peripheral neuropathies.
The results indicated that the Field Horsetail/PEA combination successfully crossed the intestinal barrier and reached the target site, modulating nerve recovery mechanisms following Schwann cell injury and providing an initial response to pain relief. Furthermore, the study demonstrated favorable absorption profiles during intestinal digestion, without damaging the epithelium and maintaining proper physiological function.
Implications and Future Research:
This research provides preliminary evidence of the effectiveness of the Field Horsetail and palmitoylethanolamide combination in alleviating peripheral neuropathy by addressing the key mechanisms of pain. The study suggests a potential nutraceutical approach to managing neuropathic pain, offering an alternative to conventional pharmaceutical therapies.
If your company wants to develop and/or make a product that alleviates peripheral neuropathy
Source: Ruga, S.; Galla, R.; Ferrari, S.; Invernizzi, M.; Uberti, F. Novel Approach to the Treatment of Neuropathic Pain Using a Combination with Palmitoylethanolamide and Equisetum arvense L. in an In Vitro Study. Int. J. Mol. Sci. 2023, 24, 5503. https://doi.org/10.3390/ijms24065503
