The administration of drugs through the oral mucosa offers significant advantages over traditional methods, such as bypassing hepatic “first-pass” elimination and preventing degradation mediated by gastric acids or digestive enzymes. This mode of administration allows for more efficient and rapid absorption of active compounds, improving their effectiveness and reducing potential systemic side effects.
Benefits of Administering Active Compounds through the Oral Mucosa
Administering active compounds through the oral mucosa offers numerous benefits:
1. Avoiding First-Pass Hepatic Elimination: When administered orally, many active compounds are metabolized in the liver before reaching the systemic circulation. Oromucosal administration bypasses this process, increasing the bioavailability of the compound.
2. Prevention of Gastric Degradation: Degradation mediated by gastric acids or digestive enzymes can significantly reduce effectiveness. Administration through the oral mucosa avoids this degradation.
3. Absorption Not Affected by Food: Unlike oral administration, oromucosal absorption is not influenced by the presence of food or variations in gastric emptying rate.
To effectively administer an active compound through the oral mucosa, prolonging the contact time between the formulation and the mucosa itself is essential. Mucoadhesion, the ability of a material to adhere to the mucosa, plays a crucial role in this process. Mucoadhesive polymers can increase contact time, improving absorption and therapeutic efficacy.
The Mucoadhesive Bioenhancer technology has proven effective in improving the bioavailability and effectiveness of active compounds administered through the oral mucosa. By utilizing cyclodextrins and understanding specialized transport mechanisms, this technology allows for more precise and prolonged administration, optimizing absorption and reducing systemic side effects. The formulation of this technology is a bioadhesive gel, which facilitates adhesion to the sublingual epithelium.
Examples of Active Compounds that Can Benefit from Mucoadhesive Bioenhancer Technology:
– Melatonin
– Vitamin D
– B Vitamins
– Folic Acid
– Coenzyme Q10
– Resveratrol
– Astaxanthin
With Mucoadhesive Bioenhancer technology, you can improve the bioavailability and effectiveness of active compounds administered through the oral mucosa