Shatavari and Perimenopause: What the Clinical Study Reveals
Perimenopause is a physiological transition that can last several years, marked by irregular menstrual cycles, hot flashes, sleep disturbances, and mood changes. For many women, this phase represents a daily challenge. However, scientific research continues to identify new natural solutions, including Asparagus racemosus (Shatavari), an Ayurvedic herb known for its role in women’s health.
The Strength of a Standardized Extract
The study published in Functional Foods in Health and Disease examines CL22209, a patented and standardized Shatavari extract developed to enhance its hormone-balancing activity. The 15% standardization in shatavarins—molecules with estrogen-like activity—is one of the key elements behind the observed efficacy.
A Rigorous 120-Day Trial
The research involved 75 women aged 40 to 50, divided into three groups: placebo, CL22209 50 mg, and CL22209 100 mg. Over a four-month period, the study assessed symptoms, hormonal parameters, number of ovarian follicles, and indicators of skin and hair quality.
Significant Improvement in Symptoms
The study showed a marked reduction in symptoms related to perimenopause:
- decrease in MRS (Menopause Rating Scale) scores
- progressive reduction in hot flashes (HFWWS) compared to placebo
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Participants also reported benefits in psychological well-being and sleep quality, two areas often compromised during the menopausal transition.
A More Stable Hormonal Balance
One of the most interesting findings is the modulation of FSH, LH, estradiol, and AMH. In the treated group, FSH and LH—typically elevated during perimenopause—decreased, while AMH and estradiol increased, suggesting an improvement in ovarian function.
A Possible Dual Mechanism of Action
According to the researchers, the beneficial effect arises from a dual mechanism:
- central action on neuroendocrine regulation
- peripheral action supporting folliculogenesis and protecting ovarian cells
This dual activity is consistent with the traditional uses of Shatavari and its antioxidant and adaptogenic properties.
Benefits Beyond Vasomotor Symptoms
Beyond hormonal parameters and common symptoms, CL22209 demonstrated a positive effect on skin and hair, which often deteriorate due to declining estrogen levels. Participants reported improved skin hydration, reduced impurities, and stronger, shinier hair.
Throughout the 120-day study, no relevant adverse effects emerged. Blood and urine parameters remained stable, confirming the excellent tolerability of the extract.
A Promising Ingredient for Dietary Supplements and Functional Foods
The study enriches the landscape of natural alternatives for perimenopause. Thanks to documented benefits on symptoms, hormones, and quality of life, Shatavari stands out as an ingredient of great interest for formulations dedicated to women’s health—effective, safe, and supported by clinical evidence.
If your company is interested in creating or manufacturing a product for Perimenopause:
Source: Yadav P., Yadav S., Vedururu S.S., Kumari G., July 22, 2025, Clinical assessment of CL22209, Functional Foods in Health and Disease
