Rhodiola crenulata: Cognitive Benefits in Hypoxic Conditions – Clinical Study
Exposure to hypoxia leads to cognitive function impairment, reducing pilots’ performance in multitasking operations. Rhodiola crenulata has demonstrated antioxidant properties in vitro and in vivo. However, its effect on hypoxia-induced cognitive impairment remains unclear. The aim of the study was to investigate the positive effects of Rhodiola on cognitive function.
Thirty-nine healthy participants were recruited for the study.
Each participant received either two capsules of Rhodiola crenulata extract or a placebo. They took these capsules two days prior to engaging in cognitive tasks. The tasks were conducted under both normal and low oxygen conditions.
Blood oxygen saturation level (SpO2) was also monitored using a pulse oximeter. The Lake Louise Acute Mountain Sickness Score Questionnaire was administered, and stress markers in saliva were measured.
Each person participated in four sessions. These sessions included normal oxygen, reduced cerebral oxygen, low oxygen, and low oxygen + reduced cerebral oxygen. The order of these sessions was randomized. Each session lasted for 30 minutes.
Hypoxia significantly reduced SpO2 levels (P < 0.05), short- and long-term memory capacity (DST), cognitive flexibility and selective attention (WCST), and executive functions (TMT types A and B).
However, preventive treatment with RCE significantly prevented hypoxia-induced reductions in SpO2 levels, DST, WCST, and TMT. Additionally, Rhodiola crenulata extract attenuated symptoms similar to mountain sickness.
Rhodiola crenulata extract helps with cognitive problems caused by lack of oxygen and could be useful in aviation settings.
If your company wishes to create or manufacture a product that exerts a beneficial effect on cognitive impairment induced by hypoxia
Source: Shih-Yu Lee, Kuen-Tze Lin, Yu Chen, Yang-Hong Dai, Rhodiola crenulata extract supplement significantly attenuates hypoxia-reduced oxygen saturation and cognitive function, Journal of Herbal Medicine, Volume 41, 2023, 100732, ISSN 2210-8033, https://doi.org/10.1016/j.hermed.2023.100732.
