The effects of curcumin in food supplement on inflammatory biomarkers in hemodialysis patients
Over the past decade, the effect of turmeric and curcumin supplementation has been evaluated on many aspects of health status in different populations.
This systematic review with meta-analysis estimated the effect of curcumin supplementation on inflammatory markers in subjects undergoing hemodialysis.
After a systematic search of the medical-scientific databases MEDLINE, EMBASE, Scopus, and Web of Science from 1997 to June 2022, nine randomized double-blind or single-blind studies were selected. This study analyzed the effects of turmeric and curcumin on inflammation in subjects undergoing hemodialysis over the age of 18 years.
Data collected from these studies indicated that the preparations containing curcumin had a significant effect on serum levels of c-reactive protein (8 studies, 467 participants) and interleukin-6 (3 studies, 153 participants) compared with the control group.
The curcumin intervention did not significantly affect the concentration of tumor necrosis factor-a (3 studies, 153 participants) compared with the placebo group.
Meta-analysis also showed that curcumin supplementation was associated with a significant reduction in serum concentrations of high-sensitivity c-reactive protein (hs-CRP) and interleukin-6 in the same population.
The effect of curcumin on reducing hs-CRP levels was greater than the minimum clinically important difference (MCIO) for c-reactive protein (0.5 mg/L).
Major limitation of the study were the small number of studies, the overall high risk of bias in the included studies, and the high heterogeneity in some results.
This meta-analysis suggested that intervention with curcumin in food supplements was associated with a significant reduction in serum concentrations of hs-CRP and IL-6 in patients with MH.
The intervention of curcumin in reducing hs-CRP levels was greater than the minimum clinically important difference (MCID) for CRP (0.5 mg/L), which may be useful in clinicians’ clinical decisions.
If your company would like to develop and/or manufacture a product for the treatment of inflammation in hemodialysis patients,
Source: Arabi SM, Bahari H, Hamidipor S, Bahrami LS, Feizy Z, Nematy M, Kesharwani P. Sahebkar A. The effects of curcumin-containing supplements on inflammatory biomarkers in hemodialysis patients: A systematic review and meta-analysis. Phytother Res. 2022 Oct 1
