Antidiabetic Effects of Tribulus Terrestris and Curcuma Amada: A Study on Animal Models
Diabetes is a metabolic disease characterized by high blood glucose levels due to low insulin secretion or insulin resistance. According to the WHO, it will be the leading cause of mortality and morbidity by 2030. Diabetes leads to secondary complications such as diabetic retinopathy and nephropathy. Often, a combination of drugs is necessary to treat diabetes and its complications, which can cause side effects.
Effective diabetes treatment remains challenging, as most available drugs are not efficient in combating diabetes, especially in secondary complications like obesity, retinopathy, and nephropathy associated with diabetes. Therefore, there is a need for drugs without adverse effects. Recent studies have examined the use of traditional medicinal plants like Tribulus Terrestris and Curcuma Amada, showing promising antidiabetic effects in animal models.
In the present study, a combined aqueous extract of Tribulus Terrestris and Curcuma Amada was administered to diabetic-induced rats for 37 days. During the experiment, the mean blood glucose level was estimated, and at the end of the experiment on the 37th day, the animals were sacrificed and observed for weight gain, plasma insulin, glycogen, glycated hemoglobin, urea, and creatinine levels.
The results revealed that diabetic groups treated with the extract of Tribulus Terrestris and Curcuma Amada significantly lowered the mean blood glucose level, followed by increased glycogen and insulin levels. Urea, creatinine, and HbA1c levels were considerably reduced in diabetic animals treated with Tribulus Terrestris and Curcuma Amada compared to those treated with the antidiabetic drug Glibenclamide.
Diabetic animals treated with Tribulus Terrestris and Curcuma Amada showed a considerable net body weight gain at the end of the experiment. In conclusion, the study demonstrates that the herbal extract of Tribulus Terrestris and Curcuma Amada is effective against diabetes and can be considered an antidiabetic agent in Ayurvedic medicine.
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Source: Kaliaperumal K, Bhat BA, Subramanian K, Ramakrishnan T, Chakravarthy E, Al-Keridis LA, Ahmad I, Alabdallah NM, Saeed M, Karunakaran R. In-vivo anti-hyperglycemic effect of herbal extracts Tribulus terrestris (L) and Curcuma amada (R) on streptozotocin-induced diabetic rats and its associated histopathological studies. Heliyon. 2024 Jan 4;10(1):e24009. doi: 10.1016/j.heliyon.2024.e24009. PMID: 38230238; PMCID: PMC10789602.
