Alternative therapeutic approaches: The efficacy of medicinal plants in the treatment of further ulcerative disorders
Ulcerative disorders represent a significant challenge to public health globally, involving the oral mucosa, large intestine, and stomach, with consequent negative impacts on patients’ quality of life.
Conventional treatments such as non-steroidal anti-inflammatory drugs (NSAIDs), proton pump inhibitors (PPIs), histamine H2 receptor antagonists (H2RAs), and cytoprotective agents have disadvantages such as mucosal lesions, decreased gastric acid secretion, and interactions with concomitant medications.
Therefore, alternative therapeutic approaches are needed to address this health issue.
Plants are rich in active metabolites in their bark, roots, leaves, fruits, and seeds and have been used for medicinal purposes since ancient times.
The use of herbal therapy is crucial, and regulations are needed to ensure the quality of products, particularly in randomized studies, to evaluate their effectiveness and safety in treating disorders.
This study aims to explore the anti-ulcer activity of medicinal plants in the treatment of peptic ulcer disease, ulcerative colitis, and aphthous ulcers. Articles were searched in Scopus and PubMed and filtered for publications from 2013 to 2023, resulting in a total of 460 from Scopus and 239 from PubMed. Articles were further selected based on title and abstract and resulted in 55 articles.
Natural products, rich in functional metabolites, have been shown to treat ulcers by protecting the mucosa, attenuating ulcerative effects, suppressing pro-inflammatory elements, and reducing bacterial presence, consequently improving patients’ quality of life.
Natural extracts have proven effective in managing other health disorders, reducing pain, and decreasing lesions.
This review provides an overview of preclinical and clinical studies on medicinal plants, focusing on their efficacy in treating such conditions.
If your company wishes to create or manufacture a product in treating conditions such as peptic ulcers, ulcerative colitis, and aphthous ulcers
Source: Prayoga DK, Aulifa DL, Budiman A, Levita J. Plants with Anti-Ulcer Activity and Mechanism: A Review of Preclinical and Clinical Studies. Drug Des Devel Ther. 2024 Feb 1;18:193-213. doi: 10.2147/DDDT.S446949. PMID: 38318501; PMCID: PMC10840521.
