Effect of Genistein Supplementation on Metabolic Parameters: Meta-Analysis and Contrasting Results
Supplementation with genistein has been studied to evaluate its effects on metabolic parameters such as BMI, lipid profiles, and homocysteine.
Genistein, a phytoestrogen found in soy, has demonstrated potential benefits in improving blood glucose, and lipid levels and reducing homocysteine.
This study included clinical trials on individuals with diverse metabolic conditions, highlighting contrasting results. It is the first meta-analysis to consider the effect of genistein on these parameters in a general population, not just in postmenopausal women.
A comprehensive systematic search was conducted in PubMed-Medline, SCOPUS, Web of Science, Embase, and Google Scholar databases.
The results showed a significant decrease in BMI (WMD = -0.19 kg/m2; 95% CI: -0.36, -0.02), fasting blood glucose (WMD = -6.2 mg/dl; 95% CI: -8.93, -3.47), insulin levels (WMD = -1.61 µU/ml; 95% CI: -2.20, -1.01), HOMA-IR (WMD = -0.65; 95% CI: -0.83, -0.47), triglycerides (WMD = -21.55 mg/dl; 95% CI: -33.83, -9.27), total cholesterol (WMD = -8.10 mg/dl; 95% CI: -14.94, -1.26), and homocysteine (WMD = -1.02 mg/dl; 95% CI: -1.86, -0.18), but not LDL-C levels (WMD = -10.68 mg/dl; 95% CI: -24.29, 2.93). Additionally, HDL-C levels were significantly increased (WMD = 3.34 mg/dl; 95% CI: 1.24, 5.43).
Genistein supplementation significantly affected glucose and lipid metabolism and homocysteine levels and could be useful in managing metabolic status.
If your company wishes to create or manufacture a product useful in managing metabolic status
