Lipedema: A Chronic and Progressive Disease and the Potential Role of Fat-Burning Supplements in Treatment
Lipedema is a chronic and progressive disease that predominantly affects women. It is characterized by an abnormal distribution of subcutaneous fat tissue, primarily in the legs and arms. This condition causes pain, swelling, and is often associated with bruising and edema.
It usually develops during puberty or other periods of hormonal change, such as menopause or childbirth.
Lipedema is often mistaken for obesity or lymphedema but does not respond well to restrictive diets or physical exercise alone.
Nutritional supplements, combined with diet and physical activity, may help manage lipedema by reducing adipose tissue and increasing muscle mass, potentially avoiding invasive surgical treatments.
The molecular pathophysiology of lipedema is not currently clear, but several studies suggest that genetics and hormonal imbalance contribute to the pathogenesis of lipedema.
Women with this condition may sometimes have a high body mass index and exhibit an appearance similar to obesity, with associated health risks similar to those of general obesity, such as diabetes and cardiovascular disorders. However, unlike common obesity, the affected adipose tissue does not respond well to diet or physical exercise alone.
Therefore, this review discusses the effects of various dietary supplements that, when combined with diet and physical exercise, can lead to fat-burning and weight loss and could potentially be important in treating lipedema.
An effective fat burner should convert stored fats into energy, mobilize and break down triglycerides in adipocytes, accelerate metabolism, and inhibit lipogenesis.
Common ingredients in fat-burning supplements include green tea, caffeine, chromium, carnitine, and conjugated linoleic acid.
The use of fat burners may work synergistically with a healthy diet and physical exercise to reduce fat deposition in patients with lipedema and address related health issues.
The effects of fat burners in human studies are sometimes contradictory, and further research is needed to test their efficacy in the treatment of lipedema.
If your company wishes to create or manufacture an effective product for the treatment of lipedema
Source: J Prev Med Hyg 2022;63(suppl.3):E169-E173
