Targeted preparation of Pueraria lobata improves clinical symptoms of cervical spondylosis by regulating the intestinal microbiota balance Cervical spondylosis refers to degenerative changes in the cervical intervertebral disc and its accessory structures, along with corresponding symptoms caused by the secondary degeneration of intervertebral joints stimulating or compressing the spinal cord, nerves, and blood vessels. The…
When is a change in a medical technical file considered significant under Art. 120(3)MDR? A Medical Device Manufacturer with a valid certificate issued by a Notified Body under Directive 90/385/EEC (AIMDD) or Directive 93/42/EEC (MDD) may place its devices on the market even after May 26, 2021 (date of full implementation of MDR (EU) 2017/745)…
Probiotici nell’esofago di Barrett: Potenziali benefici nella prevenzione e trattamento dell’adenocarcinoma esofageo If underestimated, gastroesophageal reflux can induce Barrett’s esophagus, a complex precancerous condition characterized by metaplasia at the gastroesophageal junction, where the normal squamous epithelium is altered (columnar epithelium) and can lead to the development of esophageal adenocarcinoma. The molecular pathogenesis of the disease…